Liverpool went into last Sunday's Merseyside derby on the back of five wins from their previous six league games but were held to a 1-1 draw at Anfield by Everton and then to a goalless stalemate at home against West Bromwich Albion on Wednesday.
With Shkodran Mustafi also an injury doubt, manager Arsene Wenger is running out of central defensive options.
Trippier suspension temporarily halted by FIFA
Chelsea went second in the Premier League with a comfortable 4-0 win at Burnley, on Sunday, which maintained their unbeaten start to the season.
Manchester City failed in an audacious transfer deadline day move for Leicester City midfielder Riyadh Mahrez, British media reported on Wednesday.
'I can't comment on speculation. I don't bet and I don't do the lottery - it's not my way'
News of all that transpired on and off the football field.
Following is a match by match look at the English Premier League's weekend fixtures:
Manchester City beat bottom club Sheffield United 1-0 to move three points clear of Manchester United who were held to a goalless draw at Arsenal in the Premier League on Saturday.
Liverpool manager Juergen Klopp is expecting his toughest test yet in a Merseyside derby when his side face local rivals Everton in the Premier League on Sunday.
Rooney's 50th, 150th and 200th EPL goals have all come against Manchester City.
News of all that's transpired on and off the football field
Inter will be his sixth club in a career which began when he made his debut for Anderlecht as a 16-year-old and has taken him to Chelsea, West Bromwich Albion and Everton.
Follow the latest developments from all the on-field and off-the-field action in the Premiership.
Leicester City's traumatic week ended with a 1-0 win at Cardiff City although the result was never the chief concern on a day when the tributes flowed for the Midlands club's late owner Vichai Srivaddhanaprabha who died in a helicopter crash.
Chris Rogers fell for 95, failing to turn a half-century into a hundred for the seventh Test innings in a row as Australia ended the second day of the first Test on 264 for five, 166 behind England on Thursday.
Images from EPL matches played on Saturday.
Bayern Munich wasted a two-goal lead and needed a lucky 82nd- minute winner from Joshua Kimmich to beat Borussia Dortmund 3-2 in Germany's Super Cup on Wednesday and secure their fifth title of the year.
Three of the four managers leading their teams out at Wembley for this weekend's FA Cup semi-finals will do so knowing defeat could have serious ramifications for their short-term future.
IMAGES from EPL matches played on Wednesday
A summary of Thursday's South American World Cup qualifiers.
Dutchman Ronald Koeman has signed a two-year-deal with Barcelona.
Images from the English Premier League matches played on Saturday.
Third-placed Tottenham Hotspur are peering anxiously over their shoulders after a 1-0 Premier League loss at Everton on Saturday continued a slump in form while Chelsea beat Stoke City by the same scoreline to keep the pressure on their London rivals.
The Gunners' only league defeat of the campaign was in September away to one of England's traditional top-six clubs, Manchester United, drawing criticism that their strong start to the season was based on wins against lesser opposition.
Bilic took over the reins at West Brom in 2019 and was tasked with gaining promotion from the Championship to the top flight.
The injury to the Chile forward, who was left out of the squad for Tuesday's Champions League victory over Young Boys, "will require further investigation to confirm its severity", the club added.
Former England captain Wayne Rooney hopes the country will embrace a culture of honouring its players in the near-future as he shrugged off criticism on Tuesday of his farewell international appearance against the United States.
Romelu Lukaku scored two goals for Everton, one demonstrating rare strength and skill, to knock his old side Chelsea out of the FA Cup 2-0 in a dramatic quarter-final featuring two red cards on Saturday. All the frantic action happened in the final 13 minutes with Chelsea striker Diego Costa and Everton midfielder Gareth Barry sent off but their dismissals only came after Lukaku's brilliance had put the tie beyond doubt. The powerful Belgium striker, who never fitted in at Stamford Bridge and was sold to the Merseysiders for 28 million pounds ($40.28 million) two years ago, proved irresistible with his late five-minute double, especially with a first goal destined to go down in Goodison Park folklore. As the game meandered towards a replay, Lukaku conjured a 77th-minute goal from nowhere, muscling past two defenders on the left, powering into the box and, after some nifty footwork to bamboozle Gary Cahill, firing in a left-foot effort. Everton manager Roberto Martinez hailed it "one of the great goals we will see in the FA Cup".
"When he has the ball at his feet, he can make things happen for himself and he can make things happen for other players. He is a very special player."
All the summer transfer details right here...
Manchester City manager Pep Guardiola has confirmed he is interested in signing Everton's young centre back John Stones, who has been linked with a 50 million-pounds ($65.72 million) move to the Etihad Stadium.
Real Madrid failed in their attempt to sign France striker Kylian Mbappe from Paris Saint Germain on the final day of the transfer window as Cristiano Ronaldo completed his move from Juventus to Manchester United.
Champions Leicester City will begin their Premier League title defence with a trip to newly promoted Hull City on August 13, according to the 2016-17 fixtures released on Wednesday.
English Premier League leaders Liverpool opened up a 22-point gap at the top of the table with second-half goals from Alex Oxlade-Chamberlain, Jordan Henderson and a Mohamed Salah brace giving them a 4-0 home win over Southampton. A rare double from defender Antonio Rudiger earned Chelsea a point in an entertaining 2-2 draw with third-placed Leicester City.
Chelsea moved into the Premier League's top four as Mason Mount's superb first-half goal earned them a 1-0 win at champions Liverpool who suffered a club-record fifth straight home league defeat on Thursday.
Three months after the last ball was kicked, the Premier League emerges from the shadow of the COVID-19 pandemic this week for what will be a 92-match slog to the finish.
News of all that's transpired on and off the football field
Kumar Sangakkara scored a world record equalling half century as Sri Lanka reached 214-4 at the end of the third day to leave the second Test against England delicately poised on Sunday.
Sanchez, 28, is currently in the final year of his contract. He has been linked with a move to Paris St Germain in the current transfer window.
